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Pre-exposure Prophylaxis (PrEP)

PROUD PrEP Study Results Published in The Lancet

The results of the PROUD study of HIV pre-exposure prophylaxis (PrEP) using daily tenofovir plus emtricitabine (Truvada) have now been published online in The Lancet scientific journal. PROUD, along with the other European randomized study of PrEP, Ipergay, demonstrated considerably higher levels of PrEP effectiveness in preventing HIV infections than any previous study. PrEP should now be offered routinely as part of sexual health services, says an accompanying editorial.

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U.S. PrEP Care Cascade Suggests Structural Barriers Must Be Addressed

The uptake of pre-exposure prophylaxis (PrEP) among people who need it risks being limited due to low levels of awareness, gaps in health insurance, opaque bureaucratic procedures, under-usage of medical services, and limited awareness and skills among healthcare providers, according to an analysis published online ahead of print in Clinical Infectious DiseasesAlso taking into account suboptimal adherence among some PrEP users, the researchers concluded that just 15% of gay men in Atlanta who could benefit are likely to achieve protection from HIV with PrEP.

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IAS 2015: PrEP Adherence, Sexual Behavior, and HIV and STI Incidence [VIDEO]

An open-label Truvada pre-exposure prophylaxis (PrEP) demonstration project, which included more than 500 mostly gay and bisexual men in San Francisco, Miami, and Washington, DC, showed that adherence was generally good overall -- especially among people at highest risk for HIV infection -- but there were some important disparities, researchers reported at the recent 8th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention in Vancouver.

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Half of U.S. Gay Men Using Dating Apps Have Interacted with a PrEP User

Almost half of American gay men recruited to participate in a survey via advertising on a major mobile phone dating app say that at least one potential sexual partner has said that he was taking HIV pre-exposure prophylaxis (PrEP), and even more have interacted with someone who said that he was HIV-positive but had an undetectable viral load. Many of these potential partners were looking for sex without a condom, according to the survey results, published in the August 21 online edition ofJournal of Acquired Immune Deficiency Syndromes.

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No New HIV Infections Seen Over 2.5 Years in Kaiser San Francisco PrEP Program

The number of people accessing Truvada pre-exposure prophylaxis (PrEP) through the large Kaiser Permanente San Francisco healthcare system has increased dramatically since 2012, and no new HIV infections have been reported so far, according to study results published in the September 1 advance edition of Clinical Infectious Diseases. Rates of sexually transmitted infections (STIs) were high -- reaching 50% after a year on PrEP -- and some gay men reported a drop-off in condom use, but PrEP offers an opportunity for timely STI diagnosis and treatment, the researchers said.

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