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HCV Disease Progression

Treatment of Recurrent Hepatitis C after Liver Transplantation

Hepatitis C patients with advanced liver disease may benefit from interferon-based therapy before receiving a liver transplant, but side effects are common and response rates are low, according to a systematic research review described in the January 2011 issue of Alimentary Pharmacology and Therapeutics. Injected antibodies do not prevent the new liver from becoming infected, but pegyalted interferon plus ribavirin can cures recurring HCV about 30% of the time.

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HIV Coinfection Does Not Worsen Liver Transplant Outcomes in People with Hepatitis B or C

HIV positive liver transplant recipients with hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfection did not fare worse overall than HIV negative people, according to a Spanish study presented at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) last month in Boston. Coinfected patients were less likely to experience organ rejection, but HCV recurrence was a leading cause of adverse outcomes.

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Screening for Liver Cancer in HIV/HCV Coinfected People

Nearly half of HIV/HCV coinfected individuals with liver cancer in an international study were never screened for hepatocellular carcinoma, but those who did undergo screening had their cancer detected at an earlier stage, leading to more effective treatment and improved survival, according to a report presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna.

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Does CD4 Cell Count Influence Liver Fibrosis in HIV/HCV Coinfected People?

Neither current nor lowest-ever CD4 T-cell levels were associated with hepatitis C virus (HCV) viral load or severity of liver fibrosis in HIV positive people after adjusting for other factors, according to a Spanish study presented at the recent 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) in Boston.

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Rifaximin Reduces Encephalopathy Recurrence, Improves Quality of Life in People with Liver Cirrhosis

The broad-spectrum antibiotic rifaximin (Xifaxan) improves quality of life for people with liver cirrhosis who experience recurrent episodes of hepatic encephalopathy, or brain disease, according to research presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna. Another analysis from the same study indicated that rifaximin works by lowering the level of ammonia in the blood.

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