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HCV Disease Progression

Daily Coffee Consumption Is Linked to Less Severe Liver Fibrosis

Daily caffeine consumption from about 2 cups of coffee was associated with reduced liver fibrosis, according to results of a study published in the January 2010 issue of Hepatology. The protective effect persisted after controlling for age, sex, race, weight, liver disease, and alcohol intake, though it was more pronounced in people with hepatitis C virus (HCV) infection. The researchers found, however, that consumption of decaffeinated coffee -- or of caffeine from sources other than coffee -- was not associated with reduced fibrosis.

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African Americans with Hepatitis C Have Worse Outcomes than White Patients after Liver Transplantation

African-American individuals who undergo liver transplants due to complications of hepatitis C virus (HCV) infection experience more rapid post-transplant fibrosis progression and histological inflammation compared with white patients, even though they tend to experience slower pre-transplant disease progression, according to a study presented at the recent 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2009) in Boston.

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Rapid Liver Fibrosis Progression and Successful Treatment of Acute Infection Suggest Benefits of Routine HCV Screening for HIV Positive Men

Researchers from Mt. Sinai School of Medicine presented data last week at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston that further characterize a cohort of HIV positive men with apparently sexually transmitted acute hepatitis C virus (HCV) infection. This group continues to experience more rapid than expected liver fibrosis progression. Hepatitis C treatment has been highly successful if started during the acute phase, but less so thereafter. The researchers recommended routine ALT and HCV antibody testing to allow for prompt treatment and to prevent liver disease progression.alt

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AASLD 2009: Study Looks at Factors Affecting Survival of HIV/HCV Coinfected Liver Transplant Recipients

While HIV/HCV coinfected patients can have good outcomes after liver transplantation, acute organ rejection remains a risk factor and survival does not match that of HIV negative people with hepatitis C virus (HCV) alone, according to a study presented at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2009) this month in Boston.

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Metabolic Syndrome Is Associated with Increased Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients

As reported at the Digestive Disease Week (DDW 2009) annual meeting last week in Chicago, Bhavna Malik and colleagues sought to determine whether the presence of clinical risk factors for non-alcoholic fatty liver disease (NAFLD) -- i.e., obesity, type 2 diabetes, hypertriglyceridemia (elevated triglycerides), and hypertension (high blood pressure) -- in people with hepatitis C increases the risk of progression to HCC.

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