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TAG Offers New Guide to Clinical Trials for People with Hepatitis C

The Treatment Action Group (TAG) has produced a new booklet for people considering taking part in clinical trials for new therapies for hepatitis C.alt

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4-Drug Regimen Can Cure Genotype 1 Hepatitis C in 12 Weeks

Interim results from the Phase 2 ZENITH study show that previously untreated people with HCV genotype 1 can achieve sustained response in as little as 12 weeks using a quadruple regimen consisting of telaprevir (Incivek), the experimental HCV polymerase inhibitor VX-222, pegylated interferon, and ribavirin. A newly added arm will evaluate telaprevir, VX-222, and ribavirin without interferon. alt

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PSI-7977 plus Standard Therapy Cures 100% of Genotype 2-3 Hepatitis C Patients

Pharmasset's investigational hepatitis C virus (HCV) polymerase inhibitor PSI-7977 combined with pegylated interferon/ribavirin cured 100% of people with HCV genotype 2 and 3 in the Phase 2b PROTON trial; sustained response results for hard-to-treat genotype 1 patients are expected later this year.alt

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Pipeline Report Shows Good Prospects for People with HIV, HCV, and TB

An updated summary of experimental therapies for HIV, hepatitis C virus (HCV), and tuberculosis, produced by treatment advocates with i-Base and TAG, shows rapid progress in therapies for HCV and steady progress in the area of HIV.

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TMC435 for HCV Gets Fast Tracked, Studied with PSI-7977

The HCV NS3/4A protease inhibitor TMC435 was recently given FDA Fast Track status for expedited approval; it will be studied in an all-oral regimen with the HCV polymerase inhibitor PSI-7977.alt

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