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Experimental HCV Drugs

ACH-1625 HCV Protease Inhibitor Starts Phase 2 Trial

Achillion Pharmaceuticals recently announced that the first patients have started treatment in a Phase 2 clinical trial of the experimental HCV protease inhibitor ACH-1625 plus pegylated interferon and ribavirin.

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HCV Drug TMC649128 Enters Phase 1b

A new HCV polymerase inhibitor, TMC649128, is now being tested in a Phase 1b trial, the first stage of evaluating safety and efficacy in a large number of patients.

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Sitges Meeting Discusses European Access to New Hepatitis C Drugs

Community activists, researchers, and regulatory and pharmaceutical representatives met this month in Sitges, Spain, to discuss early and expanded access to direct-acting antiviral agents for hepatitis C, especially for difficult-to-treat patients including those with HIV/HCV coinfection and cirrhosis. alt

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Vertex Licenses Alios HCV Protease Inhibitors

Vertex Pharmaceuticals and Alios BioPharma have agreed to collaborate on development of 2 novel nucleotide analog HCV NS5B polymerase inhibitor candidates, now at the preclinical stage.

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HCV Protease Inhibitor Danoprevir Promising in Early Trial

Experimental HCV protease inhibitor danoprevir (formerly RG7227 and ITMN-191) was safe and showed good antiviral activity at higher doses in a 14-day study of treatment-naive and previously treated genotype 1 chronic hepatitis C patients. alt

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