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Experimental HCV Drugs

EASL 2011: Boosted ABT-450 Improves Early Response to Interferon for Hepatitis C

Addition of the experimental HCV protease inhibitor ABT-450, boosted with ritonavir, to standard therapy increased the likelihood of complete early virological response at 12 weeks in previously untreated genotype 1 chronic hepatitis C patients.

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Idera Delays Study of TLR9 Agonist IMO-2125 for Hepatitis C

Idera Pharmaceuticals has decided to hold off on a planned clinical trial of its experimental hepatitis C drug IMO-2125, pending further toxicity data from ongoing animal studies.

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FDA Hearings Next Week on Boceprevir and Telaprevir for HCV

FDA Antiviral Drugs Advisory Committee will hear evidence for boceprevir on April 27 and telaprevir on April 28.

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EASL 2011: Tegobuvir Works Well in Triple and Quad Regimens for HCV

Gilead's HCV polymerase inhibitor tegobuvir (GS-9190) improved response rates in treatment-naive genotype 1 patients when used in various combinations with pegylated interferon, ribavirin, and the experimental protease inhibitor GS-9256, researchers reported at EASL 2011.

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Boosted Danoprevir Improves Response in Prior Null Responders

Nearly 90% of genotype 1b prior non-responder hepatitis C patients treated with ritonavir-boosted danoprevir plus pegylated interferon/ribavirin experienced early virological response at week 12, but breakthrough reached 50% for those with genotype 1a. alt

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