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Pre-exposure Prophylaxis (PrEP)

Women's HIV Prevention Trial Halts Oral Tenofovir Arm

Researchers will discontinue one arm of the VOICE study testing oral tenofovir (Viread) pills after an interim analysis by an independent monitoring board showed that the trial would be unlikely to show that the drug works better than placebo for pre-exposure prophylaxis (PrEP) to prevent HIV infection. Other study arms testing the tenofovir/emtricitabine combination pill (Truvada) and a tenofovir vaginal gel will continue. No safety concerns were identified.alt

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Many Gay Men Interested in PrEP, Experts Create Road Map

Nearly half of U.S. gay/bisexual men said they would be "very likely" to use antiretroviral drugs as pre-exposure prophylaxis (PrEP) if it significantly reduces the risk of HIV infection. Another recent study explored the effect of PrEP on condom use. These findings further inform the sometimes contentious debate about how effective PrEP will be in "real world" use, whether benefits outweigh risks, and how to provide access.

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IAS 2011: iPrEx Shows PrEP is Durable [VIDEO]

The effectiveness of biomedical approaches to prevent HIV infection was a key theme of the 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011), held July 17-20, 2011, in Rome.

Among the major studies presented, Robert Grant from the Gladstone Institute of the University of California at San Francisco described final data from the iPrEx trial, which showed that pre-exposure prophylaxis (PrEP) using tenofovir/emtricitabine (Truvada) reduced new HIV infections by 42% overall, and by more than 90% among people who demonstrated good adherence.alt

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IAS 2011: Final iPrEX Analysis Confirms PrEP Effectiveness for Gay Men

Pre-exposure prophylaxis (PrEP) was shown to be highly effective for men and transgender women who have sex with men in a completed analysis of the large iPrEx trial presented at IAS 2011, but the prevention effect was blunted by low levels of adherence.alt

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IAS 2011: HIV PrEP Effective for Heterosexuals, Discordant Couples

Two studies find that pre-exposure prophylaxis (PrEP) with tenofovir or tenofovir/emtricitabine reduces the risk of HIV infection among heterosexuals and serodiscordant couples, researchers reported at IAS 2011.

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