Back HIV Prevention Pre-exposure (PrEP)

Pre-exposure Prophylaxis (PrEP)

IAS 2011: New Studies Add Evidence that PrEP Reduces HIV Infection Risk

Pre-exposure prophylaxis (PrEP) using tenofovir/emtricitabine (the drugs in Truvada) lowers the risk of HIV transmission among heterosexuals, according to 2 African studies to be presented next week at the 6th International AIDS Society Conference of HIV Pathogenesis, Treatment and Prevention (IAS 2011).

Read more:

Women's PrEP Study Halted due to Disappointing Findings

A trial of Truvada pre-exposure prophylaxis for women in Africa was discontinued this week after an interim review found that the study was unlikely to show a reduction in HIV infections.

Read more:

CDC Issues Guidance for Truvada Pre-exposure Prophylaxis

The U.S. Centers for Disease Control and Prevention (CDC) this week issued interim guidance regarding the use of tenofovir/emtricitabine (Truvada) for pre-exposure prophylaxis (PrEP) against HIV infection. The guidelines, published in the January 28, 2011, Morbidity and Mortality Weekly Report, note the limitations of the recent iPrEx trial and recommend PrEP only for gay/bisexual men with "substantial, ongoing, high risk" for acquiring HIV.

Read more:

CROI 2011: Researchers Report Further Findings from iPrEx PrEP Trial

Investigators presented further details of findings from the ground-breaking iPrEx trial this week at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) in Boston. With longer follow-up, pre-exposure prophylaxis (PrEP) using tenofovir/emtricitabine (Truvada) continued to have a protective effect against HIV acquisition, but signs of mild bone loss raise potential concerns about safety.

alt

Read more:

U.S. Advocates Offer Strategies for Pre-exposure Prophylaxis to Prevent HIV Infection

The National PrEP Committee, a new coalition of treatment advocates, policy experts, and others, has released a report on strategies for using pre-exposure prophylaxis, or taking antiretroviral drugs as a way to prevent HIV infection. Recently published data from the iPrEx trial showed that daily use of tenofovir/emtricitabine (Truvada) reduced the risk of HIV acquisition by 44% among gay and bisexual men, but many questions remain regarding adherence, cost, and other potential concerns.

Read more: